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In the front row, hooker, Chris Brooker, comes in to replace the injured Tani Fuga, with Aston Croall filling the spot on the bench. Nick Easter comes back into the No 8 position, putting Tom Guest on the bench.
In the backs, Chris Malone returns at fly half, putting Adrian Jarvis on the bench. With Ugo Monye still injured from last week's match against Sale, David Strettle moves to outside centre.
It will be an emotional occasion for many Quins supporters when Simon Keogh pulls on the multi-coloured jersey for his last Premiership league fixture for the club, partnering Tom Williams on the wing.
Harlequins Director of Rugby, Dean Richards, said: "We travel to Leicester for the climax of this season's fixture list. It will no doubt be a huge game for both players and supporters and I am looking forward to it being a well fought match.
"It is a young and talented squad who will be making the journey to Welford Road tomorrow. We haven't given up the fourth spot yet and we are still in with a shout."
Harlequins team, v Leicester Tigers, Saturday:
1 Ceri Jones
2 Chris Brooker
3 Mike Ross
4 James Percival
5 George Robson
6 Chris Robshaw
7 Will Skinner (capt)
8 Nick Easter
9 Danny Care
10 Chris Malone
11 Simon Keogh
12 Tosh Masson
13 David Strettle
14 Tom Williams
15 Mike Brown
Replacements:
Aston Croall
John Brooks
Jim Evans
Tom Guest
Steven So'oialo
Adrian Jarvis
De Wet Barry.
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